Introduction: In recent years, attention to narrative and spatial mise-en-scène in architecture has provided a foundation for reinterpreting spatial design and user experience. This interdisciplinary approach enables the reconsideration of meaning and spatial organization in an interactive and dynamic manner.Objective: The aim of this study is to conduct a comparative analysis of two key theoretical approaches—event-based architecture in the thought of Bernard Tschumi and narrative-driven architecture in the theory of Sophia Psarra—in order to clarify the capacities of spatial mise-en-scène for narrative-based architectural design. Methodology:This research adopts a qualitative, descriptive-analytical methodology based on the comparative analysis of theories and selected case studies. The theoretical framework is grounded in the analysis of key concepts such as narrative, event, spatial semiotics, and mise-en-scène. Findings: The findings indicate that Tschumi’s event-based architecture emphasizes rupture, tension, and the interaction between space and user action, while Psarra’s approach focuses on multilayered narrative, interpretability, and the experiential aspect of space. Comparative analysis of these theories demonstrates that integrating narrative and mise-en-scène can foster the development of new conceptual models for contemporary architectural design, especially in cultural and public contexts. Conclusion: The study underlines the importance of rethinking architectural design processes through narrative-driven approaches and the necessity of employing semiotic and interpretive tools to create meaningful and participatory spaces.